Listeria Monocytogenes

OUR EARLY RESEARCH: THE IMMUNOLOGY PROJECTS ON
Listeria monocytogenes

Our interest in Listeria began with the initial demonstration of antigen processing and presentation to T cells. These studies were followed by examination of many early events in microbial infection including the role of inflammatory cytokines (IL-1, IL-6, IL-10, IL-12, TNF, and IFN-g), reactive oxygen/nitrogen species, and listeriosis in lymphocyte deficient strains of mice (SCID). Below are included three key papers on antigen processing using L. monocytogenes plus reviews covering the subsequent investigations.

Ziegler K, Unanue ER:  The specific binding of Listeria-immune T lymphocytes to macrophages. I. Quantitation, role of H-2 gene products. J Exp Med 1979;150:1143. PMID115958

Ziegler K, Unanue ER:  Identification of a macrophage antigen-processing event required for I-region-restricted antigen presentation to lymphocytes.  J Immunol 1981;127:1869. PMID6795263

Ziegler K, Unanue ER:  Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.  Proc Natl Acad Sci USA 1982;78:175. PMCID345685

Bancroft GJ, Schreiber RD, Unanue ER:  T cell-independent macrophage activation in Scid mice.  Current Topics in Microbiology and Immunology 1989;152:235-242. PMID2509143

Unanue ER:  Why Listeriosis?  A perspective on cellular immunity to infection.  Immunol Rev 1997;158:5-9. PMID9314069

Unanue ER:  Studies in Listeriosis show the strong symbiosis between the innate cellular system and the T cell response.  Immunol Rev 1997;158:11-25. PMID9314070

Carrero JA, Unanue ER:  Mechanisms and immunological effects of lymphocyte apoptosis caused by Listeria monocytogenes.  Adv Immunol 2012;113:157-174.  PMID22244583