Selected Recent Publications:

Xiaoxiao Wan, Bernd H. Zinselmeyer, Pavel N. Zakharov, Anthony N. Vomund, Ruth Taniguchi, Laura Santambrogio, Mark S. Anderson, Cheryl F. Lichti & Emil R. Unanue. Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides, Nature , 2018, in press, 10.1038/s41586-018-0341-6 


Zinselmeyer BH, Vomund AN, Saunders BT, Johnson MW, Carrero JA, Unanue ER. The resident macrophages in murine pancreatic islets are constantly probing their local environment, capturing beta cell granules and blood particles. Diabetologia. 2018 Jun;61(6):1374-1383. PubMed PMID: 29589072.


Carrero JA, McCarthy DP, Ferris ST, Wan X, Hu H, Zinselmeyer BH, Vomund AN, Unanue ER. Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice. Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10418-E10427. PubMed PMID: 29133420.


Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y, Cairns NJ, Kambal A, Loginicheva E, Gilfillan S, Cella M, Virgin HW, Unanue ER, Wang Y, Artyomov MN, Holtzman DM, Colonna M. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell. 2017 Aug 10;170(4):649-663.e13.PubMed PMID: 28802038.


Ferris ST, Zakharov PN, Wan X, Calderon B, Artyomov MN, Unanue ER, Carrero JA. The islet-resident macrophage is in an inflammatory state and senses microbial products in blood. J Exp Med. 2017 Aug 7;214(8):2369-2385. PubMed PMID: 28630088.


Wan X, Unanue ER. Unique features in the presentation of insulin epitopes in autoimmune diabetes: an update. Curr Opin Immunol. 2017 Jun;46:30-37.PubMed PMID: 28456018.


Valderrama C, Clark A, Urano F, Unanue ER, Carrero JA. Listeria monocytogenes induces an interferon-enhanced activation of the integrated stress response that is detrimental for resolution of infection in mice. Eur J Immunol. 2017 May;47(5):830-840. PubMed PMID: 28267207.


Unanue ER. Macrophages in Endocrine Glands, with Emphasis on Pancreatic Islets. Microbiol Spectr. 2016 Dec;4(6). PubMed PMID: 28084197.


Carrero JA, Ferris ST, Unanue ER. Macrophages and dendritic cells in islets of Langerhans in diabetic autoimmunity: a lesson on cell interactions in a mini-organ. Curr Opin Immunol. 2016 Dec;43:54-59.PubMed PMID: 27710840.


Unanue ER, Ferris ST, Carrero JA. The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse. Immunol Rev. 2016 Jul;272(1):183-201.PubMed PMID: 27319351.


Wan X, Thomas JW, Unanue ER. Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites. J Exp Med. 2016 May 30;213(6):967-78. PubMed PMID: 27139492.


Calderon B, Carrero JA, Ferris ST, Sojka DK, Moore L, Epelman S, Murphy KM, Yokoyama WM, Randolph GJ, Unanue ER. The pancreas anatomy conditions the origin and properties of resident macrophages. J Exp Med. 2015 Sep 21;212(10):1497-512.  Epub 2015 Sep 7. PubMed PMID: 26347472.


Vomund AN, Zinselmeyer BH, Hughes J, Calderon B, Valderrama C, Ferris ST, Wan X, Kanekura K, Carrero JA, Urano F, Unanue ER. Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5496-502. Epub 2015 Aug 31. PubMed PMID: 26324934.


Ferris ST, Carrero JA, Mohan JF, Calderon B, Murphy KM, Unanue ER:  A minor subset of Batf3-dependent antigen presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes.  Immunity 2014; 41: 657-669. PMID25367577.


Calderon B, Carrero JA, Unanue ER.  The central role of antigen presentation in islets of Langerhans in autoimmune diabetes.  Curr Opin Immunol 26C:32-40, 2014.  PMID24556398


Unanue ER and McMichael AJ.  Ita Askonas and her influence in the field of antigen presentation.  Curr Opin Immunol 26:111-114, 2014.  PMID24556407


Unanue ER, Urano F.  Endoplasmic reticulum: an interface between the immune response and metabolism.  Diabetes 63:48-49, 2014.  PMID24357695


Unanue ER.  Antigen presentation in the autoimmune diabetes of the NOD mouse.  Annu Rev Immunol 32:579-608, 2014.  PMID24499272


Carrero JA. Confounding roles for type 1 interferons during bacterial and viral pathogenesis.  Int Immunol 25:663-669, 2013. PMID24158954


Mohan JF, Calderon B, Anderson MS, Unanue ER.  Pathogenic CD4 T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes.  J Exp Med 210:2403-2414, 2013.  PMID24127484


Lee SH, Carrero JA, Uppaluri R, White JM, Archambault JM, Lai KS, Chan SR, Sheehan KCF, Unanue ER, Schreiber RD. Identifying the initiating events of anti-Listeria responses using mice with conditional loss of IFN-g receptor subunit 1 (IFNGR1).  J Immunol 191:4223-4234, 2013.  PMID24048899


Unanue ER.  Commentary - Perspectives on anti-CD47 antibody treatment for experimental cancer.  Proc Natl Acad Sci USA 110:10886-10887, 2013.  PMID23784781


Neefjes J, Unanue ER.  The ever surprising field of antigen presentation.  Mol Immunol 55:105, 2013. PMID23298870


Carrero JA, Calderon B, Towfic F, Artyomov MN, Unanue ER.  Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse.  PLoS One 8:e59701, 2013.  PMID23555752


Mohan JF, Unanue ER.  A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins implicated in autoimmunity.  Mol Immunol 55:166-168, 2013.  PMID23200226


Yang C-W, Unanue ER.  Neutrophils control the magnitude and spread of the immune response in a thromboxane A2 mediated process.  J Exp Med 210:375-387, 2013.  PMID23337807


Mohan JF, Unanue ER.  Unconventional recognition of peptides by T cells and the implications for autoimmunity.  Nat Rev Immunol 12:721-728, 2012.  PMID22955843


Unanue ER, Carrero JA.  Studies with Listeria monocytogenes lead the way.  Adv Immunol 113:1-5, 2012.  PMID22244575


Ireland JM, Unanue ER.  Processing of proteins in autophagic vesicles of antigen-presenting cells generates citrullinated peptides recognized by the immune system.  Autophagy 8:429-430, 2012.  PMID22361580


Carrero JA, Unanue ER.  Mechanisms and immunological effects of lymphocyte apoptosis caused by Listeria monocytogenes.  Adv Immunol 113:157-174, 2012.  PMID22244583


Carrero JA, Vivanco-Cid H, Unanue ER.  Listeriolysin O is strongly immunogenic independent of it cytotoxic activity.  PLoS One 7:e32310, 2012.  PMID22403645


Ireland JM, Unanue ER.  Autophagy in antigen presenting cells results in presentation of citrullinated peptides to CD4 T cells.  J Exp Med 208:2625-2632, 2011.  PMID22162830


Mohan JF, Petzold SJ, Unanue ER.  Register shifting of an autoimmune insulin peptide-MHC II complex allows for the escape of diabetogenic T cells from negative selection.  J Exp Med 208:2375-2383, 2011.  PMID22065673


Calderon B, Unanue ER.  Antigen presentation events in autoimmune diabetes.  Curr Opin Immunol 24:1-10, 2011.  PMID22178549


Edelson BT, Bradstreet TR, Kc W, Hildner K, Herzog JW, Sim J, Russell JH, Murphy TL, Unanue ER, Murphy KM.  Batf3-dependent CD11b peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.  PLoS One 6:e25660, 2011.  PMID22065991


Strong BSI, Unanue ER.  Presentation of type B peptide-MHC complexes from hen egg white lysozyme by TLR ligands and type 1 interferons independent of H2-DM regulation.  J Immunol 187:2103-2201, 2011.  PMID21788443


Edelson BT, Bradstreet TR, Hildner K, Carrero JA, Frederick KE, KC W, Belizaire R, Aoshi T, Schreiber RD, Miller MJ, Murphy TL, Unanue ER, Murphy KM.  CD8a(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes.  Immunity 35:236-248, 2011.  PMID21867927


McCartney SA, Vermi W, Lonardi S, Rossini C, Otero K, Calderon B, Gilfillan S, Diamond MS, Unanue ER, Colonna M.  RNA sensor-induced type I IFN prevents diabetes caused by a b cell-tropic virus in mice.  J Clin Invest 121:1497-1507, 2011.  PMID21403398


Calderon B, Carrero JA, Miller MJ, Unanue ER. Entry of diabetogenic T cells into islets induces changes that lead to amplification of the cellular response. Proc Natl Acad Sci USA 108:1561-1566, 2011.  PMID21220309


Calderon B, Carrero JA, Miller MJ, Unanue ER. Cellular and molecular events in the localization of diabetogenic T cells to islets of Langerhans. Proc Natl Acad Sci USA 108:1567-1572, 2011.  PMID21220322


Unanue ER. Altered peptide ligands make their entry.  J Immunol 186:7-8, 2011.  PMID21172872


Unanue ER.  Starting immunology by way of immunopathology.  Ann Rev Path 6:1-8, 2011.  PMID21261517


Atibalentja DF, Murphy KM, Unanue ER. Functional redundancy between thymic CD8a+ and Sirpa+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins.  J Immunol 186:1421-1431, 2011.  PMID21178002


Yang C-W, Strong BSI, Miller MJ, Unanue ER. Neutrophils influence the level of antigen presentation during the immune response to protein antigens in adjuvants.  J Immunol 185:2927-2934, 2010.  PMID20679530


Ise W, Kohyama M, Nutsch KM, Lee HM, Suri A, Unanue ER, Murphy TL, Murphy KM. CTLA-4 suppresses theh pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.. Nat Immunol 11:129-135, 2010 Abstract


Mohan JF, Levisetti MG, Calderon B, Herzog JW, Petzold SJ, Unanue ER. Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes.. Nat Immunol 11:350-354, 2010 Abstract


Aoshi T, Carrero J, Konjufca V, Koide Y, Unanue ER, Miller MM. The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen.. Eur J Immunol 39:417-425, 2009 Abstract


Chang KY, Unanue ER. Prediction of HLA-DQ8 cell peptidome using a computational program and its relationship to autoreactive T cells.. Int Immunol 21:705-713., 2009 Abstract


Carrero JA, Calderon B, Vivanco-Cid H, Unanue ER. Recombinant Listeria monocytogenes O is weakly virulent but immunogenic.. Infec & Immun 77:4371-4382, 2009 Abstract


Belizaire R, Unanue ER. Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation.. Proc Natl Acad Sci USA 106:17463-17468, 2009 Abstract


Atibalentja DF, Byersdorfer CA, Unanue ER. Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction.. J Immunol 183:7909-7918, 2009 Abstract


Carrero JA, Vivanco-Cid H, Unanue ER. Granzymes drive a rapid listeriolysin O-induced T cell apoptosis.. J Immunol 181:1365-1374, 2008 Abstract


Suri A, Levisetti MG, Unanue ER. Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity?. Curr Opin Immunol 20:105-110., 2008 Abstract


Unanue ER, McCluskey J. Dressing for the occasion: APCs make antigens presentable.. Curr Opin Immunol 20:49-51, 2008 Abstract


Suri A, Walters JJ, Rohrs HW, Gross ML, Unanue ER. First signature of islet β-cell-derived naturally processed peptides selected by diabetogenic class II MHC molecules.. J Immunol 180:3849-3856, 2008 Abstract


Calderon B, Suri A, Miller MJ, Unanue ER. Dendritic cells in islets of Langerhans constitutively present beta cell derived peptides bound to their class II MHC molecules.. Proc Natl Acad Sci USA 105:6121-6126., 2008 Abstract


Levisetti MG, Lewis DM, Suri A, Unanue ER. Weak proinsulin peptide-MHC complexes are targeted in autoimmune diabetes in mice.. Diabetes; in press., 2008 Abstract


Akilesh S, Huber TB, Wu H, Wang G, Hartleben B, Kopp JB, Miner JH, Roopenian DC, Unanue ER, Shaw AS. Podocytes use FcRn to clear IgG from the glomerular basement membrane.. Proc Natl Acad Sci USA 105:973-978., 2008 Abstract


Calderon B, Suri A, Pan XO, Mills JC, Unanue ER. Interferon-gamma-dependent regulatory circuits in immune inflammation highlighted in diabetes. J Immunol 181:6964-6974, 2008 Abstract


Hildner K, Edelson BT, Purtha WE, Diamond M, Matsushita H, Kohyama M, Calderon B, Schraml BU, Unanue ER, Diamond MS, Schreiber RD, Murphy TL, Murphy KM. Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity.. Science 322:1097-1100, 2008 Abstract


Unanue ER. Viral infections and non-specific protection: good or bad?. New Eng J Med 357:1345-1346., 2007 Abstract


Levisetti MG, Suri A, Petzold SJ, Unanue ER. The insulin-specific T cells of NOD mice recognize a weak MHC-binding segment in more than one register. J Immunol 178:6051-6057, 2007 Abstract


Lovitch SB, Esparza TJ, Schweitzer G, Herzog J, Unanue ER. Activation of type B T cells after protein immunization reveals novel pathways of in vivo presentation of peptides. J Immunol 178:122-133, 2007 Abstract


Chang KY, Suri A, Unanue ER. Predicting peptides bound to I-Ag7 class II histocompatibility molecules using a novel expectation-maximization alignment algorithm.. Proteomics 7:367-377, 2007 Abstract


Unanue ER. Ito cells, stellate cells, and myofibroblasts: new actors in antigen presentation. Immunity 9-10, 2007 Abstract


Suri A, Unanue ER. Response to comment on Suri et al. on diabetes reversal in NOD mice. Science 311:1778-1780., 2006 Abstract


Carrero JA, Unanue ER. Impact of lymphocyte apoptosis on the innate stages of infection.. Immunol Res 2006;in press, 2006 Abstract


Carrero JA, Unanue ER. Lymphocyte apoptosis as an immune subversion strategy of microbial pathogens.. Trends in Immunology 27:497-503, 2006 Abstract


Unanue ER. From antigen processing to peptide-MHC binding. Nature Immunol 7:1277-1279, 2006 Abstract


Ireland J, Herzog J, Unanue ER. Cutting edge: T cells specifically recognize citrullinated peptides after immunization with protein antigens. J Immunol 177:1421-1425, 2006 Abstract


Calderon B, Suri A, Unanue ER. In CD4 T cell-induced diabetes, macrophages are the final effector cells that mediate islet β cell killing: Studies from an acute model.. Am J Path 169:2137-2147, 2006 Abstract


Suri A, Walters JJ, Levisetti MG, Gross ML, Unanue ER. Identification of naturally processed peptides bound to the class I MHC molecule H-2Kd of normal and TAP-deficient cells. Eur J Immunol 36:544-557, 2006 Abstract


Lovitch SB, Pu Z, Unanue ER. Amino-terminal flanking residues determine the conformation of a peptide-class II MHC complex. J Immunol 176:2958-2968, 2006 Abstract


Suri A, Calderon B, Esparza TJ, Frederick K, Bittner P, Unanue E. Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells. Science 311:1778-1780, 2006 Abstract


Carrero J, Calderon B, Unanue ER. Lymphocytes are detrimental during the early innate immune response against L. monocytogenes. J Exp Med 203:993-940, 2006 Abstract


Suri A, Lovitch SB, Unanue ER. The wide diversity and complexity of peptides bound to class II MHC molecules. Curr Opin Immunol 18:70-77, 2006 Abstract


Unanue ER. The symbiotic relationship between phagocytes and lymphocytes in immune responses.. Koch Foundation, Berlin, Germany. October, 2005, 2005 Abstract


Lovitch SB, Unanue ER. Conformational isomers of a peptide-class II MHC complex. Immunol Rev 207:293-313, 2005 Abstract


Suri A, Unanue ER. The murine diabetogenic class II histocompatibility molecule I-Ag7: structural and functional properties and specificity of peptide selection. Adv Immunol 88:235-265, 2005 Abstract


Byersdorfer CA, Schweitzer GG, Unanue ER. Diabetes is predicted by the beta cell level of autoantigen. J Immunol 175:4347-4354, 2005 Abstract


Suri A, Walters JJ, Gross M, Unanue ER. Natural peptides selected by diabetogenic DQ8 and murine I-Ag7 molecules show common sequence specificity. J Clin Invest 115:2268-2276, 2005 Abstract


Herzog J, Maekawa Y, Cirrito TP, Illian BS, Unanue ER. Activated antigen presenting cells select and present chemically modified peptides recognized by unique CD4 T cells. Proc Natl Acad Sci USA 102:7928-7933, 2005 Abstract